Karen Mainenti has had solo exhibitions of her work at the 2019 SPRING/BREAK Art Show, The Bard Graduate Center Library, Ground Floor Gallery, The Society for Domestic Museology, and Chashama. Select group exhibitions include the Untitled Space, DUMBO Arts Festival, The National Arts Club, Louise Nevelson Chapel, Guest Spot @ The Reinstitute in Baltimore and the Cornell Museum of Art in Delray Beach, Florida. Her artwork has received coverage in ARTnews, Artnet News, Hyperallergic, Gothamist, Brooklyn Magazine, Gallery Gurls and The Believer Magazine, among others. In 2018 she was an Artist-in-Residence at the Bard Graduate Center Library. Mainenti is deeply connected to the Gowanus, Brooklyn arts community through collaboration with artist Sasha Chavchavadze on Footnote project space and serving on the Board of Directors of Arts Gowanus.