In 1996, she moved to New Orleans, where she lives with her artist husband, Stephen Paul Day. Besides working individually, they also collaborate and exhibit under the name Club S&S.
Peretti is using two-dimensional kiln-formed glass panels that she combines with painting, photography, and drawing. She often pairs them with three-dimensional lost-wax castings.
The works are narratives about the beautiful and poetic yet disrupted relationship between humans and the natural world.
Her panels and sculptures are an affirmation of life, as well as a warning of the impending loss—societal & environmental—that she has witnessed in the industrial wastelands of her native Germany and the eroding and increasingly flooded lowlands of her adopted Louisiana home.
Peretti has won numerous awards and endorsements, including grants from the Pollock-Krasner Foundation and the Joan Mitchell Foundation. In 2012/13, she received a United States Artist Fellowship.
She was a resident artist at the Arts/Industry Program at Kohler Art Center in Sheboygan, WI. And was awarded four residencies at Wheaton Arts in Millville, NJ.
In 2018, her work was featured in a solo exhibition, Promise and Perception: The Enchanted Landscapes of Sibylle Peretti, at the Chrysler Museum of Art.
Peretti’s work is included in the collection of the Toledo Museum of Art, Toledo OH, The Barry Art Museum, Norfolk VA, Corning Museum of Glass, Corning NY, Carnegie Museum of Art, Pittsburg PA, Speed Museum, Louisville KY, Montreal Museum of Fine Arts, Canada, Museum of Applied arts, Frankfurt GER, Imagine Museum, St. Petersburg FL, Alexander–Tutsek Foundation, Munich GER, New Orleans Museum of Art, New Orleans LA,
Shanghai Museum of Glass, China, Hunter Museum of American Art, Chattanooga, TN, The Ringling Museum, Sarasota, FL, among others.